3 July 2020

New publication from Liu Group in PNAS

The Liu Group from the Center for Chromosome Stability, Department of Cellular and Molecular Medicine, have demonstrated that human cells can employ mitotic DNA synthesis to rescue failed replication at the fragile X syndrome locus (FRAXA) when cells are deprived of folate. They show that this rescue process occurs via a homologous recombination-dependent pathway called break-induced DNA replication (BIR) and requires the SLX1/SLX4 endonuclease complex, the RAD51 recombinase and POLD3, a subunit of polymerase delta. These findings provide new insight into the diverse and detrimental consequences of folate deficiency in human cells.

Read more of the publication “Folate stress induces SLX1- and RAD51-dependent mitotic DNA synthesis at the fragile X locus in human cells” (https://www.pnas.org/content/early/2020/06/24/1921219117)