Center for Chromosome Stability

The Center for Chromosome Stability (CCS) was established in March 2015 through a generous grant of 65 Mio. DKK (approx. 8.5 Mio Euro) from the Danish National Research Foundation (DNRF) as part of their Centers of Excellence programme. This grant covers an initial funding period of 6 years, following which the CCS will be reviewed with a view to a possible extension for a further 4 years.

The CCS is based in the Department of Cellular and Molecular Medicine, Panum Institute, and has strong connections to the Nordea Center for Healthy Aging, the Department of Biology and the NNF Center for Protein Research, where two of the Center’s PIs are based (see below).

The mission of the CCS is to conduct basic research in order to understand in mechanistic detail how cells minimize damage that can generate chromosomal instability. More specifically, the main focus is on regions of eukaryotic genomes that, due to their structure, are intrinsically unstable. These regions, which we term ‘the enemies within’, include chromosomal fragile sites, repeated DNA sequences and telomeres. An important longer term aim is to understand how genome instability triggers age-associated disorders in humans, including cancer, neurodegeneration and impaired fertility. The different teams possess complementary expertise in genetics, biochemistry and molecular/cell biology. The leaders of the Center’s research teams are listed below, with a link in each case provided to the home page of that team.

Ian Hickson Mechanism of chromosomal fragile site instability
Eva Hoffmann  Chromosome dynamics in the germline
Michael Lisby High throughput screening for modulators of genome stability
Ying Liu
Analysis of tri-nucleotide repeat instability
Andres Lopez-Contreras
Mouse models of DNA replication stress
Niels Mailand
DNA damage and replication stress signaling
Luis Toledo
Regulatory fundaments of DNA replication

schematic draft of workflow