Research – University of Copenhagen

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Research findings indicate that chromosome instability is an underlying cause of aging related disorders, including cancer and neurodegenerative diseases. Changes in chromosome number and structure can be triggered not only by DNA damaging agents, but also by intrinsically unstable regions of the human genome itself - which we term the
‘enemies within’. The overarching goal of the Center for Chromosome Stability (CCS) is to functionally annotate these ‘enemies within’, and determine how they drive tissue aging and limit cell immortality.

The CCS initially comprised 7 research teams, but an eighth team, headed by Associate Professor Luis Toledo joined the Center September 2016. The different teams possess complementary expertise in genetics, biochemistry and molecular/cell biology. The leaders of the Center’s research teams are listed below, with a link in each case provided to the home page of that team. One of the PIs, Eva Hoffmann, moved her laboratory to Copenhagen from the UK in mid 2015.

Ian Hickson Mechanism of chromosomal fragile site instability
Eva Hoffmann  Chromosome dynamics in the germline
Michael Lisby High throughput screening for modulators of genome stability
Ying Liu
Analysis of tri-nucleotide repeat instability
Andres Lopez-Contreras
Mouse models of DNA replication stress
Niels Mailand
DNA damage and replication stress signaling
Luis Toledo
Regulatory fundaments of DNA replication