It is well established that chromosome instability is an underlying cause of several age-related disorders, including cancer and neurodegenerative diseases. Changes in chromosome number and structure can be triggered not only by DNA damaging agents, but also by intrinsically unstable regions of the human genome itself – which we term the ‘enemies within’. The overarching goal of the Center for Chromosome Stability (CCS) is to functionally annotate these ‘enemies within’, and determine how they drive tissue aging and limit cell immortality.

The CCS currently comprises 7 research teams. The different teams possess complementary expertise in genetics, biochemistry and molecular/cell biology. The leaders of the Center’s research teams are listed below, with a short description of research interest and a link in to the home page of that team.